Birth Date ＆ Place:
01/15/1987 Tangshan, Hebei Province
Hobbies:
Tennis, workout
Education:
2015.11-2021.05, Indiana University, College of Chemistry, Ph.D.
2011.09-2014.06, Nankai University, College of Chemistry, M.S.
2007.09-2011.06, Tangshan Normal University, School of Chemistry and Material Science, B.S
Present:
Eli Lilly and Company, 1223 W Morris St, Indianapolis, IN 46221, US
Identity in group:
Master Degree
Graduation/ Resignation Year:
2014
Papers:
1. Zhang, Z.; Ramirez, L. M.; Lin, H.; Madugula, S.; Liao, Z.; Graham, S. S.; Hetrick, E. M.; Pack, B. W.; Hoaglund Hyzer, C. S.; Tiwari, R. Intrinsic Stability and Forced Degradation Profiling of a siRNA Drug Product. Mol. Pharmaceutics. 2026, submitted.
2. Zhang, Z.; Samaddar, S.; Oman, T. J.; Graham, S. S.; Hetrick, E. M.; Pack, B. W. Predicting Long-Term Stability of siRNA Solutions Using Accelerated Predictive Stability Studies. Org. Process Res. Dev. 2026, 30, 1474–1482.
3. Becket, D.; El-Baba, T. J.; Zhang, Z.; Clemmer, D. E.; Raghavachari, K. Tautomerization of H+KPGG: Entropic Consequences of Strong Hydrogen-Bond Networks in Peptides. J. Phys. Chem. A 2023, 127, 6282–6291.
4. Zhang, Z.; Hales, D. A.; Clemmer, D. E. Influence of N Terminus Amino Acid on Peptide Cleavage in Solution through Diketopiperazine Formation. J. Am. Soc. Mass Spectrom. 2022, 33, 1368–1376.
5. Zhang, Z.; Conant, C. R.; El-Baba, T. J.; Raab, S. A.; Fuller, D. R.; Hales, D. A.; Clemmer, D. E. Diketopiperazine formation from FPGnK (n = 1–9) peptides: Rates of structural rearrangements and mechanisms. J. Phys. Chem. B 2021, 125, 8107–8116.
6. Zhang, Z.; Raab, S. A.; Hales, D. A.; Clemmer, D. E. Understanding the influence of solvents on Diketopiperazine formation of peptide FPG5K. J. Phys. Chem. B 2021, 125, 2952–2959.
7. Sahota, N.; AbuSalim, D.; Wang, M. L.; Brown, J. C.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. A microdroplet-catalyzed Biginelli reaction: acceleration, mechanisms and separation of isomers using IMS-MS. Chem. Sci. 2019, 10, 4822–4827.
8. Conant, C. R.; Fuller, D. R.; Zhang, Z.; Woodall, D. W.; Russell, D. H.; Clemmer, D. E. Substance P in the gas phase: conformational changes and dissociations induced by collisional activation in a drift tube. J. Am. Soc. Mass Spectrom. 2019, 30, 932–945.
9. Conant, C. R.; Fuller, D. R.; El-Baba, T. J.; Zhang, Z.; Russell, D. H.; Clemmer, D. E. Substance P in solution: trans-to-cis configurationaal changes of penultimate prolines initiate non-enzymatic peptide bond cleavages. J. Am. Soc. Mass Spectrom. 2019, 30, 919–931.
10. Fuller, D. R.; Conant, C. R.; El-Baba, T. J.; Zhang, Z.; Molloy, K. R.; Zhang, C. S.; Hales, D. A.; Russell, D. H.; Clemmer, D. E. Monitoring the stabilities of a mixture of peptides by mass-spectrometry-based techniques. Eur. J. Mass Spectrom. 2019, 25, 73–81.
11. Xu, B.; Zhu, S.; Zhang, Z.; Yu, Z.; Ma, Y.; Zhou, Q. Highly enantioselective S–H bond insertion cooperatively catalyzed by dirhodium complexes and chiral spiro phosphoric acids. Chem. Sci. 2014, 5, 1442–1448.
12. Xu, B.; Zhu, S.; Zuo, X.; Zhang, Z.; Zhou, Q. Enantioselective N–H insertion reaction of α-aryl α-diazoketones: an efficient route to chiral α-aminoketones. Angew. Chem. Int. Ed. 2014, 53, 3913–3916. (Selected as Very Important Paper).
